Management of breast lesions without cellular atypia is primarily symptomatic. Tissue biopsy, usually a core-needle biopsy, is indicated if there is a clinical suspicion of malignancy. The diagnosis is made during the workup of symptoms (e.g., mastalgia, palpable breast mass, nipple discharge) or incidentally on clinical breast examination and/or imaging. Patients typically present with premenstrual bilateral multifocal breast pain with or without palpable nodules, which may be tender. ![]() Histologically, fibrocystic changes are divided into nonproliferative breast lesions (e.g., simple breast cysts, apocrine metaplasia) and proliferative breast lesions (e.g., ductal epithelial hyperplasia, sclerosing adenosis). Women between 20 and 50 years of age are most commonly affected. 2019 Nov 01 20(11):3299-3304.Fibrocystic breast changes is a nonspecific term that includes a heterogeneous spectrum of breast conditions. Risk Factor Analysis for Breast Cancer in Premenopausal and Postmenopausal Women of Punjab, India. Kour A, Sharma S, Sambyal V, Guleria K, Singh NR, Uppal MS, Manjari M, Sudan M, Kukreja S. Schünemann HJ, Lerda D, Quinn C, Follmann M, Alonso-Coello P, Rossi PG, Lebeau A, Nyström L, Broeders M, Ioannidou-Mouzaka L, Duffy SW, Borisch B, Fitzpatrick P, Hofvind S, Castells X, Giordano L, Canelo-Aybar C, Warman S, Mansel R, Sardanelli F, Parmelli E, Gräwingholt A, Saz-Parkinson Z, European Commission Initiative on Breast Cancer (ECIBC) Contributor Group Breast Cancer Screening and Diagnosis: A Synopsis of the European Breast Guidelines. Preliminary Results Supporting the Bacterial Hypothesis in Red Breast Syndrome following Postmastectomy Acellular Dermal Matrix- and Implant-Based Reconstructions. 2019 Dec 143(12):1492-1496.ĭanino MA, El Khatib AM, Doucet O, Dao L, Efanov JI, Bou-Merhi JS, Iliescu-Nelea M. Metaplastic Breast Carcinoma: Update on Histopathology and Molecular Alterations. Prevalence of antibiotic resistant mastitis pathogens in dairy cows in Egypt and potential biological control agents produced from plant endophytic actinobacteria. During the reproductive age, glandular breast tissue has a direct relation to cyclical surges of plasma levels of estradiol and progesterone.Ĭopyright © 2023, StatPearls Publishing LLC.Īmeen F, Reda SA, El-Shatoury SA, Riad EM, Enany ME, Alarfaj AA. These components include the stroma, ducts, and lobules of the breast. ![]() The main components of the breast are prone to fibrocystic changes during hormonal fluctuations. The most common investigative tools to assess for these clinical findings are mammograms and ultrasound. ![]() ![]() The clinical findings include symptoms such as dimpling of the skin (peau d'orange), thickening, pain, and nipple discharge. A palpable mass upon clinical evaluation is evident in both benign and malignant breast conditions. The above-mentioned benign lesions are not associated with an increased risk for malignancy however, it associates with an up to 50% risk of developing breast cancer under certain histopathological and clinical circumstances. Benign breast disease is an umbrella term for various non-malignant lesions, such as tumors, trauma, mastalgia, and nipple discharge. Certain hormonal factors underpin the function, evaluation, and treatment of this disease. Fibrocystic breast disease is the most common benign type of breast disease, diagnosed in millions of women worldwide.
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